The Outagamie County Regional Airport is home to many unique tenants. Gulfstream Aerospace is located on the field and provides maintenance on a variety of corporate jets in addition to finish work on all new Gulfstream corporate jets.

Air Wisconsin Airlines Corporation has their corporate headquarters located at the airport. While it has operated a maintenance facility here since 1989, Air Wisconsin began in Appleton nearly the same time the airport opened at its present location.

Gulfstream and Air Wisconsin employ approximately 1,000 personnel.

Outagamie County Regional Airport is also serviced by Northwest Airlink, Comair (Delta), Midwest Connect Airlines, United Express.

The Outagamie County Regional Airport currently has two air cargo operations—Airborne Express (DHL) and Federal Express. Both facilities provide overnight, next day and freight service. Together they employ approximately 100 personnel.